Abstract ISG15. an interferon-stimulated ubiquitin-like protein. plays a multifaceted role in tumorigenesis and immune regulation. This study comprehensively evaluates ISG15 as a prognostic biomarker and predictor of immunotherapy response through pan-cancer bioinformatics analysis and experimental validation. https://thegreensjunglebeautyshops.shop/product-category/kids-swimwear/